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The most popular South Dakota State University undergraduate major is Registered Nursing/Registered Nurse. Mechanical Engineering and Animal Sciences, General are other popular majors.
| Registered Nursing/Registered Nurse | 315 |
| Animal Sciences, General | 90 |
| Psychology, General | 80 |
| Mechanical Engineering | 69 |
| Biomedical Sciences, General | 66 |
| Pharmaceutics and Drug Design | 64 |
| Agribusiness/Agricultural Business Operations | 60 |
| Early Childhood Education and Teaching | 58 |
| Human Development and Family Studies, General | 56 |
| Business/Managerial Economics | 52 |
| Statistics, General | 42 |
| Agronomy and Crop Science | 38 |
| Construction Management, General | 38 |
| Sociology, General | 38 |
| AGRICULTURAL/ANIMAL/PLANT/VETERINARY SCIENCE AND RELATED FIELDS | 34 |
| Wildlife, Fish and Wildlands Science and Management | 34 |
| Civil Engineering, General | 31 |
| Exercise Science and Kinesiology | 29 |
| Consumer Economics | 28 |
| Clinical Laboratory Science/Medical Technology/Technologist | 27 |
| Graphic Design | 27 |
| Mathematics, General | 26 |
| Computer and Information Sciences, General | 25 |
| General Studies | 25 |
| Biology/Biological Sciences, General | 23 |
| Electrical and Electronics Engineering | 23 |
| Physical Education Teaching and Coaching | 20 |
| Interior Design | 19 |
| Community Health and Preventive Medicine | 18 |
| Spanish Language and Literature | 18 |
| Advertising | 17 |
| Agricultural Mechanization, General | 17 |
| AGRICULTURAL/ANIMAL/PLANT/VETERINARY SCIENCE AND RELATED FIELDS | 17 |
| Economics, General | 17 |
| Human Nutrition | 17 |
| Political Science and Government, General | 17 |
| Speech Communication and Rhetoric | 17 |
| Agricultural Production Operations, General | 16 |
| Biochemistry | 15 |
| Dairy Science | 15 |
| History, General | 15 |
| Music Teacher Education | 13 |
| Agricultural Teacher Education | 12 |
| Architectural and Building Sciences/Technology | 12 |
| MULTI/INTERDISCIPLINARY STUDIES | 12 |
| Parks, Recreation, and Leisure Facilities Management, General | 12 |
| Environmental/Natural Resources Law Enforcement and Protective Services | 11 |
| Electrical, Electronic, and Communications Engineering Technology/Technician | 10 |
| Engineering/Industrial Management | 10 |
| Entrepreneurship/Entrepreneurial Studies | 10 |
| Geography | 10 |
| Microbiology, General | 10 |
| Apparel and Textile Marketing Management | 9 |
| English Language and Literature, General | 9 |
| Environmental Studies | 9 |
| Flight Instructor | 9 |
| Journalism | 9 |
| Hospitality Administration/Management, General | 8 |
| Agricultural Engineering | 7 |
| Natural Resources/Conservation, General | 7 |
| Public Relations/Image Management | 7 |
| Chemistry, General | 6 |
| Microbiology, General | 6 |
| Respiratory Care Therapy/Therapist | 6 |
| Biotechnology | 5 |
| Drama and Dramatics/Theatre Arts, General | 5 |
| Fine/Studio Arts, General | 5 |
| Landscape Architecture | 5 |
| Organizational Leadership | 5 |
| Range Science and Management | 5 |
| Agricultural Production Operations, General | 4 |
| Geographic Information Science and Cartography | 4 |
| Music, General | 4 |
| Non-Profit/Public/Organizational Management | 4 |
| Political Science and Government, General | 4 |
| Applied Horticulture/Horticulture Operations, General | 3 |
| Business/Managerial Economics | 3 |
| Chemistry, General | 3 |
| Dairy Science | 3 |
| International/Globalization Studies | 3 |
| Physics, General | 3 |
| Speech Communication and Rhetoric | 3 |
| Agribusiness/Agricultural Business Operations | 2 |
| Animal Sciences, General | 2 |
| Biotechnology | 2 |
| Chemistry Teacher Education | 2 |
| Entrepreneurship/Entrepreneurial Studies | 2 |
| Environmental/Natural Resources Law Enforcement and Protective Services | 2 |
| Family and Consumer Sciences/Home Economics Teacher Education | 2 |
| Geographic Information Science and Cartography | 2 |
| Geography | 2 |
| International/Globalization Studies | 2 |
| Sociology, General | 2 |
| Wildlife, Fish and Wildlands Science and Management | 2 |
| Aeronautics/Aviation/Aerospace Science and Technology, General | 1 |
| Agricultural Mechanization, General | 1 |
| Agronomy and Crop Science | 1 |
| Biochemistry | 1 |
| Biology/Biological Sciences, General | 1 |
| Biomedical Sciences, General | 1 |
| Chemistry Teacher Education | 1 |
| City/Urban, Community, and Regional Planning | 1 |
| Economics, General | 1 |
| Food Science | 1 |
| French Language and Literature | 1 |
| French Language and Literature | 1 |
| German Language and Literature | 1 |
| Psychology, General | 1 |
| Spanish Language and Literature | 1 |
| Agricultural Economics | 0 |
| American Indian/Native American Studies | 0 |
| Animal Health | 0 |
| Athletic Training/Trainer | 0 |
| Dietetics/Dietitian | 0 |
| Energy, Environment, and Natural Resources Law | 0 |
| Foods, Nutrition, and Wellness Studies, General | 0 |
| Health and Wellness, General | 0 |
| Liberal Arts and Sciences/Liberal Studies | 0 |
| Visual and Performing Arts, General | 0 |
The data on this website is sourced as public domain data from the most recent survey year of the National Center for Education Statistics’ College Navigator tool. That tool can be found at this link: https://nces.ed.gov/collegenavigator/. MyCollegeSelection encourages students to explore multiple resources as part of the research process in selecting the college of their dreams.